Amyotrophic lateral sclerosis, one of the degenerative neurological diseases, is also referred to as a motor neuron disease. The incidence rate is 1-2.5/100,000 and it mainly occurs in adults and occurs 1.5 times more in males.

Amyotrophic lateral sclerosis generally refers to clinical syndromes caused by the dysfunction of the upper and lower motor neurons. In the United States, it is more commonly known as Lou Gehrig's disease.

Some of the symptoms including respiratory muscular weakness, dysarthria, dysphagia, fatigability and respiratory difficulties are all caused through signs of the upper and lower motor neurons.

It is critical when diagnosing amyotrophic lateral sclerosis, along with other diseases is a thorough examination of the patients' medical history and neurological testing. Examining the signs of the upper and lower motor neurons is particularly important. Through electromyography, neurophysiological test, radioactive examination and blood test, the disease must be clearly distinguished from any other disease that might occur with similar symptoms.

Even though various attempts, including gene therapy, are being made in terms of treatment, there is no current known cure as of now. A drug called riluzole is currently being used, but it is not quite effective. Just like many other muscular diseases, general respiratory treatments along with the prevention of complications, a sufficient supply of nutrients and pulmonary rehabilitation could prove helpful.